Despite the composition and characteristics of an intestinal microbiota "healthy" are not yet well defined, it is known that perturbations of the composition of the microflora of the gastro-intestinal tract are associated with an increased risk of immune-mediated diseases .
The growing interest in the effects of the intestinal microbiota in human health has prompted the development of strategies to optimize the microbial ecosystem and stressed the importance of nutrition and lifestyle in maintaining the abundance, variety and diversity of the intestinal microflora.
Rebalancing a state of dysbiosis is still a complex operation because the microbial populations that have most influence immunological homeostasis are anaerobic bacteria which can hardly be built from the outside, through the use of biomodulator (probiotics, prebiotics, synbiotics, postbiotics).
Therefore, acquiring a healthy lifestyle and a diet that can provide the body with several active substances, it is essential not only to reduce the risk of immune-mediated diseases in adults but also to promote a good immunological maturation in early life (core microbiota).
Icaza Chavez ME (2013) Gut microbiota in health and disease. Rev Gastr Mex 78(4): 240-248.
Pearson C, Uhlig HH, Powrie F (2012) Lymphoid microenvironments and innate lymphoid cells in the gut. Trends Immunol 33(6): 289-296.
Peterson CT, Sharma V, Elmén L, Peterson SN (2015) Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota.
Clin Exp Immunol 179(3): 363-377.
Salzman NH (2014) The role of the microbiome in immune cell development. Ann Allergy Asthma Immunol 113(6): 593-598.
Dejea CM, Wick EC, Hechenbleikner EM, White JR, Mark Welch JL (2014) Microbiota organization is a distinct feature of proximal colorectal cancers. Proc Natl Acad Sci U S A 111(51): 18321-18326.
Cario E (2005) Bacterial interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2. Gut 54(8): 1182-1193.
Gao Z, Guo B, Gao R, Zhu Q, Qin H (2015) Microbiota disbiosis is associated with colorectal cancer. Front Microb 6: 20.
Vannucci L, Krizan J, Sima P, Stakheev D, Caja F, et al. (2013) Immunostimulatory properties and antitumor activities of glucans. Int J Oncol 43(2): 357-364.
Bogwald J, Johnson E, Seljelid R (1982) The Cytotoxic Effect of Mouse Macrophages Stimulated in vitro by a '-1,3-d-Glucan from Yeast Cell Walls. Scandinavian Journal of Immunology 15(3): 297-304.
Di Luzio NR, McNamee RB, Williams DL, Gilbert KM, Spanjers MA (1979) Glucan induced inhibition of tumor growth and enhancement of survival in a variety of transplantable and spontaneous murine tumor models Adv Exp Med BioI 121(A): 269-290.
Seljelid RA (1986) Water-soluble aminated beta-i, 3D-glu-can derivative causes regression of solid tumors in mice. Biosci Rep Sett 6(9): 845-851.
Vetvicka V, Vetvickova J (2012) Combination of glucan, resveratrol and vitamin C demonstrates strong anti-tumor potential. Anticancer Res 32(1): 81-87.
Vetvicka V, Volny T, Saraswat-Ohri S, Vashishta A, Vancikova Z, et al. (2007) Glucan and resveratrol complex, possible synergistic effects on immune system. Biom Pap Med Fac Univ Palacky Olom Czech Rep 151(1): 41-46.
Blaut M (2002) Relationship of prebiotics and food to intestinal microflora. Eur J Nutr 41 Suppl 1: i11-i16.
Annalisa N, Alessio T, Claudette TD, Erald V, Antonino de L, et al. (2014) Gut microbioma population: an indicator really sensible to any change in age, diet, metabolic syndrome, and life-style. Mediators Inflamm 2014: 901308.